scholarly journals Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy

Cancer ◽  
1989 ◽  
Vol 63 (8) ◽  
pp. 1477-1486 ◽  
Author(s):  
Gaetano Bacci ◽  
Aldo Toni ◽  
Maddalena Avella ◽  
Marco Manfrini ◽  
Alessandra Sudanese ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Combined Therapy ◽  
Long Term Results

scholarly journals Long-Term Results of Ewing’s Sarcoma—In a Single Institution

2013 ◽  
Vol 04 (01) ◽  
pp. 323-330 ◽  
Author(s):  
Jae Do Kim ◽  
Tae Hun Kim ◽  
So Hak Chung
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Long Term Results ◽  
Single Institution

A long-term review of the treatment of patients with Ewing's sarcoma in one institution

2001 ◽  
Vol 27 (6) ◽  
pp. 569-573 ◽  
Author(s):  
M. Sluga ◽  
R. Windhager ◽  
S. Lang ◽  
H. Heinzl ◽  
P. Krepler ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma

Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study.

1990 ◽  
Vol 8 (10) ◽  
pp. 1664-1674 ◽  
Author(s):  
M E Nesbit ◽  
E A Gehan ◽  
E O Burgert ◽  
T J Vietti ◽  
A Cangir ◽  
...  
Keyword(s):  
Overall Survival ◽  
Local Recurrence ◽  
Multimodal Therapy ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Patient Characteristics ◽  
Group I ◽  
Long Term Follow Up

A total of 342 previously untreated eligible children were entered into the first Intergroup Ewing's Sarcoma Study (IESS) between May 1973 and November 1978. In group I institutions, patients were randomized between treatment 1 (radiotherapy to primary lesion plus cyclophosphamide, vincristine, dactinomycin, and Adriamycin [doxorubicin; Adria Laboratories, Columbus, OH] [VAC plus ADR]) or treatment 2 (same as treatment 1 without ADR), and group II institutions randomized patients between treatment 2 or treatment 3 (same as treatment 2 plus bilateral pulmonary radiotherapy [VAC plus BPR]). The percentages of patients relapse-free and surviving (RFS) at 5 years for treatments 1, 2, and 3 were 60%, 24%, and 44%, respectively. There was strong statistical evidence of a significant advantage in RFS for treatment 1 (VAC plus ADR) versus 2 (VAC alone) (P less than .001) and 3 (P less than .05) and also of treatment 3 versus 2 (P less than .001). Similar significant results were observed with respect to overall survival. Patients with disease at pelvic sites have significantly poorer survival at 5 years than those with disease at nonpelvic sites (34% v 57%; P less than .001). Among pelvic cases, there was no evidence of differing survival by treatment (P = .81), but among nonpelvic cases, there was strong evidence of differing survival by treatment (P less than .001). The overall percentage of patients developing metastatic disease was 44%; the percentages by treatments 1, 2, and 3 were 30%, 72%, and 42%, respectively. The overall incidence of local recurrence was 15%, and there was no evidence that local recurrence rate differed by treatment. Patient characteristics related to prognosis, both with respect to RFS and overall survival experience, were primary site (nonpelvic patients were most favorable) and patient age (younger patients were more favorable).

Ewing’s sarcoma (EW): Long-term favourable outcome in children with combined modality therapy and conservative surgery

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 8561-8561
Author(s):  
N. Delepine ◽  
F. Delepine ◽  
H. Cornille ◽  
S. Alkalaf ◽  
A. Tabbi ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Combined Modality Therapy ◽  
Conservative Surgery ◽  
Favourable Outcome ◽  
Combined Modality

scholarly journals A rare case of acute paraplegia: primary Ewing’s Sarcoma of dorsal spine

2018 ◽  
Vol 5 (5) ◽  
pp. 1927
Author(s):  
Yeshwant Kumar N. N. T. ◽  
V. T. T. Rajan
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Postoperative Outcome ◽  
Cord Compression ◽  
Acute Onset ◽  
Radical Excision ◽  
Benign Condition ◽  
Acute Paraplegia ◽  
Primary Bone

Ewing's sarcoma is a primary bone malignancy with the highest incidence in the second decade of life. Although it mostly affects the metaphyseal region of long growing bones, involvement of spine is not very uncommon especially the sacrum. Non-sacral spinal Ewing's sarcoma is rarer and often mimics a benign condition before spreading extensively. They present with neurologic deficits due to spinal cord compression, but acute onset paraplegia has not been previously reported. A high index of clinical suspicion can clinch the diagnosis early in the course of the disease. A prompt intervention is required to keep neurological damage to a minimum, and a correct combination of surgery, chemotherapy, and radiotherapy is required for better long-term patient outcome. We report a 11-year-old female who presented with acute paraplegia and had an excellent postoperative outcome after radical excision of a C7-D2 Ewing's sarcoma.

Chemotherapy plus radiotherapy (CT-RT) versus RT alone for patients with anaplastic oligodendroglioma: Long-term results of the RTOG 9402 phase III study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 2008b-2008b ◽  
Author(s):  
J. Gregory Cairncross ◽  
Meihua Wang ◽  
Edward G. Shaw ◽  
Robert B. Jenkins ◽  
Bernd W. Scheithauer ◽  
...  
Keyword(s):  
Combined Therapy ◽  
Progression Free Survival ◽  
Phase Iii ◽  
Long Term Results ◽  
Phase Iii Trial ◽  
Free Survival ◽  
Entire Cohort ◽  
Phase Iii Study

2008b Background: Anaplastic oligodendrogliomas, pure (AO) and mixed (AOA), are chemosensitive tumors, especially if co-deleted for chromosomes 1p and 19q, but whether addition of CT to RT prolongs overall survival (OS), is unknown. Methods: In the RTOG 9402 Phase III trial, patients (pts) with AO/AOA were randomly assigned to PCV [procarbazine, CCNU (lomustine) and vincristine] followed by immediate RT vs. immediate RT alone. Early analysis showed no OS benefit for the PCV+RT group but combined therapy was associated with a longer progression-free survival (PFS). It also showed that the finding of 1p/19q co-deletion was associated with a longer OS independent of treatment. The current analysis has a median follow up of 11.3 years (yrs). Results: Two hundred ninety-one patients were randomized, 148 to PCV+RT and 143 to RT. PCV+RT was associated with longer PFS [2.5 vs. 1.7 yrs, hazard ratio (HR) 0.68, 95% confidence interval (CI) (0.53, 0.88), P = 0.003] and the 1p/19q co-deletion with a longer Median Survival Time (MST) [8.7 vs. 2.7 yrs, HR 0.41, 95% CI (0.30, 0.55), P < 0.001]. For the entire cohort, there was no difference in MST by treatment [4.6 yrs for PCV+RT vs. 4.7 yrs for RT, HR 0.79, 95% CI (0.60, 1.04), P = 0.1]. However, patients with 1p/19q co-deleted tumors lived much longer after PCV+RT (n = 59) than after RT (n = 67) [14.7 vs. 7.3 yrs, HR 0.59, 95% CI (0.37, 0.95), P = 0.03]. There was no difference in MST by treatment in pts without the 1p/19q co-deletion [n=137; 2.6 vs. 2.7 yrs, HR 0.85, 95% CI (0.58, 1.23), P = 0.39]. Re-operation rates upon progression were similar between treatment arms in co-deleted pts (43%, PCV+RT vs. 54%, RT) but salvage CT rates were higher in the RT arm [57% vs. 81% (P = 0.04)]. Conclusions: PCV followed by immediate RT was a highly effective therapy for patients with 1p/19q co-deleted AO/AOA. In this setting, 1p/19q co-deletion was both prognostic and predictive, and the early PFS benefit in co-deleted cases was a harbinger of their longer OS. [This work was supported by RTOG grants U10 CA21661 and U10 CA32115, NCCTG grant U10 CA25224, ECOG grants CA17145 and CA21115, SWOG grant CA32102, and CCOP grant U10 CA37422 from the National Cancer Institute (NCI)]

Short- and long-term results after surgical treatment of an ununited anconeal process in the dog

2001 ◽  
Vol 14 (02) ◽  
pp. 101-110 ◽  
Author(s):  
M. Felir ◽  
I. Molte ◽  
A. Meyer-Lindenberg
Keyword(s):  
Surgical Treatment ◽  
Combined Therapy ◽  
Prospective Trial ◽  
Long Term Results ◽  
German Shepherd ◽  
Single Measure ◽  
Proximal Ulna ◽  
Post Operation ◽  
Short And Long Term

SummaryIn a prospective trial over seven years (1993-1999), 44 joints from 41 dogs with an ununited anconeal process are reported. The average age of the animals was 23 weeks. With regard to breed distribution, the German Shepherd was most frequently represented with 29 animals.In 35 joints, the anconeal process was stabilised with lag screw and pin, as there was no fibrous connection between the anconeal process and the ulna. Additionally, in all cases an ulna ostectomy was performed. In nine joints, the connection of the anconeal process to the olecranon was firm and only a proximal ulna ostectomy was performed. The patients were rechecked clinically and radiologically, at an average of 13 weeks post operation. With one exception, in all of the cases the apophysis was closed. The implants were removed in 25 patients. The surgical results were examined once more after an average of 20 months in 43 joints (40 dogs). 83.7% of the cases (n = 36) did not show any lameness after the combined therapy with fixation of the isolated anconeal process and osteotomy of the ulna (n = 28) or ulna ostectomy only (n = 8) and were assessed as ‘good’. Six dogs (five with fixation, one with ostectomy) showed some degree of lameness after heavy strain and were only evaluated as ‘satisfactory’. One dog still had a striking low to medium grade lameness, so that the result was regarded as ‘unsatisfactory’. With regard to the development of arthrosis, only nine of the 30 joints (30%) examined radiographically showed a mild increase of the arthroses during later examinations.In many cases excision of the ununited anconeal process leads to unsatisfactory long-term results. Frequently surgical treatment does not lead to fusion. This paper describes a concept for treatment of an ununited anconeal process and the short- and long-term results. Proximal ostectomy of the ulna was performed, as a single measure, when the anconeal process was tightly in place. In joints with a loose anconeal process, the piece of bone was stabilised with implants, in addition to an ostectomy of the ulna. After an average of three months, the anconeal process had fused with the ulna, in all hut one case. In long-term follow-ups, after an average of 20 months, most of the dogs did not show any lameness, even after exercise. In only a few joints was a minor increase of arthrosis noted. The technique described is considered to be useful to treat the ununited anconeal process in young dogs.

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